Dana-Farber Checkpoint Candidate Aims to Rival
Keytruda®and Libtayo®on More Than Cost

A PD-L1 checkpoint inhibitor discovered at the Dana-Farber Cancer Institute is on its way to showing efficacy in line with Merck’s Keytruda and Regeneron/Sanofi’s Libtayo, with potentially better tolerability.

But the clinical developer of the candidate, Checkpoint Therapeutics (Nasdaq: CKPT), doesn’t plan to end there.

The company is planning a rapid adoption strategy of discount pricing in a $25 billion market now dominated by six drugs, each selling for about $165K a year.

Interim data released at last year’s ESMO showed the candidate cosibelimab running neck-in-neck with Keytruda and Libtayo in efficacy measures, with potentially better tolerability.

A pivotal trial is now underway in cSCC, a potentially lethal skin cancer, giving it direct aim at Libtayo with estimated sales of over $300 million this year.  Next up will be a clinical program in NSCLC, currently the main indication for Merck’s Keytruda, a $13 billion franchise.

CKPT ended 1Q20 with $21.5 million in cash and cash equivalents.

Condensed Overview

CEO James Oliviero briefly details a drug development program designed to disrupt pricing and diminish the dominance of key leaders in a $25 billion corner of the cancer therapy market. 
(Approx. 8 minutes)

CKPT At A Glance


Adds details of CKPT’s second lead program – this one is taking aim at AstraZeneca’s Tagrisso, a blockbuster lung cancer drug.

Corporate Presentation

Learn how checkpoint inhibitors work and why they are so popular; includes more detail from James on the company’s two lead programs. 
(Approx. 23 minutes)

Visit Checkpoint's website


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